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課程名稱 |
高等化學生物學專論一
Discussion in Advanced Chemical Biology (Ⅰ) |
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開課學期 |
100-1 |
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授課對象 |
生命科學院 生化科學研究所 |
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授課教師 |
牟中原 |
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課號 |
Chem8037 |
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課程識別碼 |
223ED1660 |
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班次 |
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學分 |
4 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期一5,6(12:20~14:10)星期四5,6(12:20~14:10) |
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上課地點 |
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備註 |
本課程以英語授課。上課教室：化217教室。本課程同為CBMB-TIGP中MB組必修-基礎化學生物及生物物理學。與林俊宏合開
限博士班
總人數上限：20人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1001Chem8037 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
1. Carbohydrate: fundamental coverage (terminology and biological functions)
2. Carbohydrate: glycan-binding proteins and medical applications
3. Carbohydrate: protection chemistry
4. Carbohydrate: glycosylation
5. Protein: fundamental coverage (structure, sequence analysis, etc)
6. Protein: solid phase peptide synthesis
7. Protein: enzyme kinetics, catalytic mechanism
8. Nucleic acid: fundamental coverage (structure, sequence analysis, etc)
9. Nucleic acid: synthesis (solid phase synthesis, PCR)
10. Nucleic acid: Recombinant DNA technology
11. Special topic 1: Combinatorial synthesis and High throughput screening (optional)
12. Special topic 2: Specific cell imaging (FRET, GFP, Click chemistry-based method)
13. Special topic 3: protein-protein interaction
14. Special topic 4: Activity-based probes
15. Student presentations
Evaluations (in color red): (1) Written exam on Dec 12, (2) Oral, group presentations on Dec 29–Jan 9 (papers will be assigned). |
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課程目標 |
1. Carbohydrate
2. Protein
3. Nucleic acid
4. Special topic 1: Combinatorial synthesis and High throughput screening (optional)
5. Special topic 2: Specific cell imaging (FRET, GFP, Click chemistry-based method)
6. Special topic 3: protein-protein interaction
7. Special topic 4: Activity-based probes
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
“Essentials of Glycobiology" 2nd Edition, by Varki A., Cummings R.D., Esko
J.D., et al., editors.Cold Spring Harbor (NY): Cold Spring Harbor Laboratory
Press; 2009.
“Essentials of carbohydrate chemistry and biochemistry” 3rd edition, by
Lindhorst T.K., ed. 2007. |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
9/15 |
Course introduction |
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第2週 |
9/19,9/22 |
Carbohydrate: fundamental coverage (terminology and biological functions) |
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第3週 |
9/26,9/29 |
Carbohydrate: glycan-binding proteins and medical applications |
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第4週 |
10/3, 10/6 |
Carbohydrate: protection chemistry |
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第5週 |
10/13* |
Carbohydrate: glycosylation |
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第6週 |
10/17,10/20 |
Protein: fundamental coverage (structure, sequence analysis, etc) |
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第7週 |
10/24,10/27 |
Protein: enzyme kinetics, catalytic mechanism (Mou) |
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第8週 |
10/31,11/03 |
Protein: protein function and solid phase peptide synthesis |
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第9週 |
11/07,11/10 |
Nucleic acid: fundamental coverage (structure, sequence analysis, etc) |
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第10週 |
11/14,11/17 |
Nucleic acid: synthesis (solid phase synthesis, PCR) |
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第11週 |
11/21*,11/24* |
Nucleic acid: Recombinant DNA technology |
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第12週 |
11/28,12/01 |
Special topic 1: Combinatorial synthesis and High throughput screening |
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第13週 |
12/05 12/08 |
Specific cell imaging |
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第14週 |
12/12 |
Examination |
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第15週 |
12/19,12/22 |
Special topic 3: Protein-protein interaction (Mou) |
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第16週 |
12/26,12/29 |
Special topic 4: Activity-based probes
Student presentations
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第17週 |
1/02,1/05 |
Student presentations |
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